Orfadin (Nitisinone)

The drug, Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase that is used as the additional dietary restriction of Tyrosine and Phenylalanine for treating hereditary tyrosinemia type 1 (HT-1). 

Recommended dosage : Healthcare professionals recommend a dose of Orfadin as 1 to 2 mg/kg divided into 2 daily doses. And the initial dose is 1 mg/kg/day, divided into morning and evening administration.

Note: Orfadin is an FDA-approved drug.

The drug, Nitisinone, is an inhibitor of 4-hydroxyphenyl-pyruvate dioxygenase, an enzyme in the tyrosine metabolic pathway. Therefore, treatment with Nitisinone may cause an increase in blood tyrosine in patients with HT-1, and patients should maintain a concomitant reduction in dietary tyrosine and phenylalanine while on Nitisinone treatment. One should maintain plasma tyrosine levels below 500 mol/L. 

• Ocular signs and symptoms are reported in patients treated with Nitisinone, such as corneal ulcers, keratitis, conjunctivitis, corneal opacities, eye pain, and photophobia.
• Few patients who took Nitisinone experienced an abrupt change in neurologic status. 
• Patients also experienced painful hyperkeratotic plaques on the soles and palms. 

Reports show patients treated with Nitisinone and dietary restriction developed transient leucopenia, thrombocytopenia, or both. There is one case where a patient developed leukopenia and thrombocytopenia improved after the dose of Nitisinone decreased from 2 mg/kg to 1 mg/kg. One should monitor platelet, and white blood cell counts regularly during Nitisinone therapy. 

What documents are required to import Orfadin to India?

Orfadin (Nitisinone) can be imported only by patients or government hospitals under the patients’ names.

The following documentation is needed to import the product:

• A valid prescription from a qualified doctor.
• Patients diagnostic reports.
• Patients Identity proof (issued by the Government of India).

How does the order get confirmed?

The order will be confirmed only after the receipt of:

• A valid prescription by healthcare professionals.
• Import permit, if applicable.

Is ORFADIN available in India?

ORFADIN (Nitisinone capsules) is a prescription drug that legally requires a medical prescription to be dispensed.

Urgent Meds helps import cancer medicines on the named patient supply (NPS). Urgent Meds is the facilitator providing input on:

• Availability of Orfadin in India.
• Medicine Price.
• Finding genuine and reliable sources from Canada, Europe, the USA, and Australia.
• Ensuring 100% transparency.

Orfadin can be made available to patients, doctors, and hospitals in Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, Pune, and other cities in India. The order will be confirmed only after receiving a valid prescription from the doctor and an import permit.

Urgent Meds can facilitate the supply of Orfadin (prescription medicines) to all locations in the world and India after fulfilling the legal requirements (if applicable).

Please get in touch with +1-647-818-4196 or visit urgentmeds.in for Orfadin price in India.

We guarantee quality and delivery worldwide per the buyer’s requirements.

Urgent Meds is proficient in sourcing ORFADIN (Medicines from around the world and has the capability to supply it. We offer global access to the best available treatment for our customers worldwide.

Urgent Meds is committed to dispensing any valid prescription promptly. All prescriptions are dispensed and verified by registered pharmacists and are dispatched only to the patient’s address from New Delhi, India. Your health and well-being are our top priorities.