Trikafta (elexacaftor, tezacaftor and ivacaftor

Trikafta is a combination of ivacaftor, a CFTR potentiator, tezacaftor, and elexacaftor used for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one F508del mutation in the CFTR gene or a mutation in the CFTR gene that is responsive.

Recommended Dosage: The recommended morning and the evening dose should be taken orally approximately 12 hours apart. Swallow tablets whole. The trikafta tablets should be taken with fat-containing food. Examples of snacks or meals that contain fat are those prepared with oils, or butter or those containing cheeses, eggs, nuts, whole milk, or meats. 

Recommended Dosage for Adult and Pediatric Patients aged 6 to less than 12 years weighing less than 30 kgs:

• Morning Dose: Two tablets, each containing elexacaftor 50 mg/tezacaftor 25 mg/ivacaftor 37.5 mg. 
• Evening Dose: One tablet of ivacaftor 75 mg

Recommended Dosage for Adult and Pediatric Patients aged 6 to less than 12 years weighing 30 kgs or more:

• Morning Dose: Two tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg
• Evening Dose: One tablet of ivacaftor 150 mg

Recommended Dosage for Adult and Pediatric Patients aged 12 years and older: 

• Morning Dose: Two tablets, each containing elexacaftor 100 mg/tezacaftor 50 mg/ivacaftor 75 mg
• Evening Dose: One tablet of ivacaftor 150 mg

In case 6 or less hours have passed since the missed or skipped morning or evening dose, the patient should take the missed dose as promptly as possible and continue on the original schedule. 

In case more than 6 hours have passed since:

the missed/skipped morning dose, the patient should take the missed/skipped dose as promptly as possible and should not take the evening dose. The next scheduled morning dose needs to be taken at around the usual time.

the missed/skipped evening dose, the patient should not take the missed/skipped dose. The next scheduled morning dose needs to be taken at around the usual time. 

Morning and evening doses must not be taken at the same time.

• Elevated transaminases have been observed in patients with trikafta cystic fibrosis medicine. Bilirubin elevations have also been seen with this treatment. Assessments of ALT, AST, and bilirubin are recommended for all patients before initiating Trikafta, every three months during the first year of therapy, and annually thereafter. 
• Exposure to ivacaftor is significantly decreased and exposure to elexacaftor and tezacaftor are expected to decrease by the concomitant use of strong CYP3A inducers, which may scale down the therapeutic effectiveness of drug Trikafta. Therefore, use of this medication with strong CYP3A inducers is not recommended. 
• Exposure to elexacaftor 50 mg, tezacaftor 25 mg and ivacaftor 37.5 mg are increased when used together with strong/moderate CYP3A inhibitors. Therefore, the dosage of Trikafta needs to be reduced when used concomitantly with moderate/strong CYP3A inhibitors. 
• Cases of non-congenital lens opacities have been seen in pediatric patients treated with ivacaftor-containing regimens. Although other risk factors existed in some cases (such as corticosteroid use, exposure to radiation), a possible risk attributable to therapy with ivacaftor cannot be excluded. Follow-up ophthalmological examinations are required in pediatric patients initiating therapy with Trikafta. 

• What documents are required to import TRIKAFTA to India?

  TRIKAFTA (elexacaftor, tezacaftor, and ivacaftor) tablets can be imported by patients or government hospitals in the name of the patients only.

  The following documentation is required to import the product:

  • Valid prescription from a qualified doctor.
  • Patients diagnostic reports.
  • Patients Identity Proof (issued by the Government of India).

  How does the order get confirmed?

  The order will be confirmed only after the receipt of:

  • Valid prescription of Doctor.
  • Import permit, if applicable.

  Is TRIKAFTA available in India?

  TRIKAFTA (elexacaftor/tezacaftor/ivacaftor tablet) is a prescription drug that legally requires a medical prescription to be dispensed.

  Urgent Meds helps import medicines on the named patient supply (NPS). Urgent Meds is the facilitator providing input on:

  • Availability of Trikafta in India (Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, and Pune, etc.).
  • Medicine Price.
  • Finding genuine and reliable sources from Canada, Europe, the USA, and Australia.
  • Ensuring 100% transparency.

  TRIKAFTA can be made available to patients, doctors, and hospitals in Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, Pune, and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and an import permit.

  Urgent Meds can facilitate the supply of TRIKAFTA (prescription medicines) to all locations in the world and in India after fulfilling the legal requirements (if applicable).

  Please contact +1-647-818-4196 or visit urgentmeds.in for TRIKAFTA tablet price in India.

  We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Urgent Meds is proficient in sourcing TRIKAFTA (Cancer Treatment Medicines) Medicines from around the world and has the capability to supply it. We offer global access to the best available treatment for our customers worldwide.

Urgent Meds is committed to dispensing any valid prescription promptly. All prescriptions are dispensed and verified by registered pharmacists and are dispatched only to the patient’s address from New Delhi, India. Your health and well-being are our top priorities.

What is the Generic Name for the trade name drug Trikafta®?

Elexacaftor/Ivacaftor/Tezacaftor is the Generic Name for the trade name drug Trikafta®.

What is the Manufacturer Name of Trikafta®?

Trikafta® is manufactured by Vertex Pharmaceuticals Incorporated.

Is Trikafta® approved by the FDA?

Yes, Trikafta® is approved by the FDA. Date of approval: October 21, 2019.

Where has Trikafta® been approved?

This medication has received regulatory approval in 32 nations, including 27 within the EMA centralized regulatory approval, as well as in the United States (US), United Kingdom (UK), Liechtenstein, Norway, and Iceland.

What is the dosage and form of Trikafta® supplied?

Trikafta® is supplied as a fixed-dose combination drug containing elexacaftor, tezacaftor, and ivacaftor, co-packaged with ivacaftor for oral administration.

What are the most common side effects due to Trikafta®?

The most common side effects of Trikafta® may include:

• Influenza
• Headache
• Upper respiratory tract infection
• Abdominal pain
• Diarrhea
• Increased alanine aminotransferase
• Nasal congestion
• Rhinorrhea
• Rhinitis
• Sinusitis
• Rash
• Increased blood bilirubin

How much does Trikafta® cost in India?

The Trikafta cost in India is very reasonable and can vary. To procure this Cystic fibrosis (CF) medication authentically, you can call or WhatsApp +1-647-818-4196 or visit urgentmeds.in.

What are the storage conditions of Trikafta®?

Store at 68 to 77°F (20 to 25°C); excursions permitted to 59 to 86°F (15 to 30°C). Do not use this medicine after the expiration date mentioned on the package.

Is it safe to buy Trikafta® online in India?

Yes, you can buy Trikafta tablets online in India authentically from urgentmeds.in if Trikafta has not been approved or is not available in your country.

Is Urgent Meds certified by WHO-GDP and ISO 9001:2008 authorities?

Yes, Urgent Meds has certification from top authorities like WHO-GDP and ISO 9001:2008. We are the leading Supplier and Wholesaler of Trikafta in India and can help you get this Cystic Fibrosis (CF) medicine at the lowest affordable price.