Symdeko (Tezacaftor/Ivacaftor & Ivacaftor)

Symdeko is a fixed dose combination (FDC) of tezacaftor and ivacaftor, used to treat patients with cystic fibrosis (CF) aged 12 years and older who have a couple of copies of the F508del mutation, or who have at least one mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that is responsive to Symdeko (tezacaftor/ivacaftor). 

If the patient’s genotype is not known, a CF mutation test should be considered in order to detect the existence of a CFTR mutation followed by verification with bi-directional sequencing when required by the mutation test instructions for use.

Recommended Dosage: The recommended dosage for Adults, Adolescents, and Children Aged 12 Years and Older is one tablet (tezacaftor 100 mg/ivacaftor 150 mg) taken in the morning and one tablet (ivacaftor 150 mg) taken in the evening, around 12 hours apart. Medicine Symdeko is for oral use. Patients should completely swallow the tablets. Take with fat-containing food, such as foods or snacks that contain fat and those prepared with oils or butter or those containing cheeses, nuts, eggs, whole milk, or meats. 

In case 6 hours or less have passed since the missed or skipped morning or evening dose, the patient should take the missed/skipped dose as promptly as possible and continue on the standard schedule.

In case more than 6 hours have passed since the missed or skipped morning or evening dose, the patient should not take the missed/skipped dose. Take the very next scheduled dose of Symdeko at around the usual time. It is not advisable to take more than a single dose at the same time.

• Elevated transaminases may be observed in those with CF treated with symdeko tablets, as well as with ivacaftor monotherapy. Assessments of ALT and AST are required for all patients before the start of treatment, every 90 days during the first year of treatment, and annually thereafter. For those with a history of transaminase elevations more frequent monitoring is required.
• Exposure to ivacaftor is significantly reduced and exposure to tezacaftor may be decreased by the concomitant administration of CYP3A inducers, which may scale down the therapeutic effectiveness of medicine symdeko. Therefore, do not co-administer this medication with strong CYP3A inducers.
• Cases of non-congenital lens opacities may occur in pediatric patients treated with drug symdeko, as well as with ivacaftor monotherapy. A possible risk attributable to therapy with Tezacaftor/Ivacaftor and Ivacaftor cannot be excluded. Perform baseline and follow-up ophthalmological examinations in pediatric patients starting therapy with Tezacaftor/Ivacaftor and Ivacaftor. 
• Do not take (tezacaftor 100 mg/ivacaftor 150 mg) if you take certain medications or herbal supplements such as: antibiotics such as rifabutin (Mycobutin), rifampin (Rifater, Rifamate), seizure medicines such as carbamazepine, phenobarbital (Carbatrol, Tegretol, Equetro), or phenytoin (Phenytek, Dilantin), snd St. John’s wort.
• Symdeko treatment may cause dizziness in some individuals who take it. Avoid driving a car, using machinery, or doing anything that requires full alertness until they know how this medication affects them. Avoid food or drink that contains grapefruit or Seville oranges while on Symdeko treatment.
• The medicine Symdeko should always be taken with a fat-containing food/meal or snack to help the body absorb the medication. Be sure to avoid meals/foods and drinks that are known to contain grapefruit while taking Symdeko because they may be responsible for affecting the existence of Symdeko in the body.

What documents are required to import SYMDEKO to India?

SYMDEKO (tezacaftor/ivacaftor; ivacaftor) tablets can be imported by patients or government hospitals on the name of the patients only.

The following documentation is required to import the product:

• Valid prescription from a qualified doctor.
• Patient’s diagnostic reports.
• Patient’s ID Proof (issued by the Government of India).

How does the order get confirmed?

The order will be confirmed only after the receipt of:

• Valid prescription from the doctor.
• Import permit, if applicable.

Is SYMDEKO available in India?

SYMDEKO (tezacaftor/ivacaftor; ivacaftor) tablets is a pharmaceutical drug that legally requires a medical prescription to be dispensed.

Urgent Meds helps import medications on the named patient supply (NPS). We provide assistance with:

• Availability of SYMDEKO in India (Hyderabad, Mumbai, Kolkata, Chennai, Ahmedabad, Delhi, Bangalore, Pune, etc.).
• Medicine price.
• Finding genuine and reliable sources from Canada, Europe, USA, and Australia.
• Ensuring 100% transparency.

SYMDEKO can be made available to patients, doctors, and hospitals at Mumbai, Kolkata, Hyderabad, Chennai, Ahmedabad, Delhi, Bangalore, Srinagar, Jammu, Jaipur, Chandigarh, Ludhiana, Noida, Gurgaon, Lucknow, Pune, and other cities in India. The order will be confirmed only after the receipt of a valid prescription from the doctor and import permit.

Urgent Meds can facilitate the supply of SYMDEKO (prescription medicines) to all locations in the world and in India after fulfilling the legal requirements (if applicable).

Please contact +1-647-818-4196 or write to us at info@urgentmeds.in for SYMDEKO price in India.

We guarantee quality and delivery anywhere in the world as per the buyer’s requirements.

Urgent Meds is proficient in sourcing SYMDEKO (Cancer Treatment Medicines) from around the world and has the capability to supply it. We offer global access to the best available treatment for our customers worldwide.

Urgent Meds is committed to dispensing any valid prescription promptly. All prescriptions are dispensed and verified by registered pharmacists and are dispatched only to the patient’s address from New Delhi, India. Your health and well-being are our top priorities.

What is the Generic Name for the trade name drug Symdeko®?

Tezacaftor/Ivacaftor and Ivacaftor are the generic names for the trade name drug Symdeko®.

What is the Manufacturer Name of Symdeko®?

Symdeko® is manufactured by Vertex Pharmaceuticals Incorporated.

Is Symdeko® approved by the FDA?

Yes, Symdeko® is approved by the FDA. The date of approval was February 12, 2018.

Where can I get Symdeko® at the best price in India?

To get the best Symdeko price in India, contact Urgent Meds (a WHO-GDP & ISO 9001:2008 authorized company). A valid medical prescription is required to purchase Symdeko®.

What is the dosage and form of Symdeko® supplied?

Symdeko® is co-packaged as:

• Tezacaftor 100 mg/Ivacaftor 150 mg fixed-dose combination tablets.
• Ivacaftor 150 mg tablets. Both forms are supplied for oral administration.

How is Symdeko® packaged?

Each box of Symdeko mainly contains 4 weekly wallets. Each weekly wallet typically contains 14 tablets.

What are the most common side effects with Symdeko®?

The most common side effects with Symdeko® include:

• Sinus congestion
• Headache
• Nausea
• Dizziness

How much does Symdeko® cost in India?

The cost of Symdeko in India can vary. To procure this cystic fibrosis (CF) medicine authentically, you can call or WhatsApp +1-647-818-4196 or send an email to info@urgentmeds.in.

What are the storage conditions of Symdeko®?

Store at 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C to 30°C (59°F to 86°F).

Is it safe to buy Symdeko® online from India?

Yes, you can buy Symdeko online in India at the best price from Urgent Meds if Symdeko® has not been approved or is not available in your country.